Medusa from The Rescuers

Frame by frame drawings of Madame Medusa by Milt Kahl. Again, he creates a believable yet cartoonish person in his drawing. Her expressions are stretched and exaggerated, with her mouth much wider open than a human mouth would normally allow, and her eyes so wise they bore into the back of her head. Her arms and fingers are so spindly and look like they could snap easily, and her skin is pulled taught across her face and neck to show her age and declining looks.

Source: http://2dtraditionalanimation.tumblr.com/post/99708258900/medusa-milt-kahl